The molecular basis of frontotemporal dementia.

Assessment of Aphasia in Iranian Patients Suffering From Frontotemporal Dementia

Objective Frontotemporal dementia (FTD) is an uncommon type of dementia. The hallmark feature of FTD is the presentation with aphasia, or behavioral changes which are varies in different subtypes of the disease. We propose a quantitative aphasia test as an additive diagnostic tool for differentiation of FTD subtypes. Method: The study was performed on 20 patients, who were referred to dementia...

IBMPFD and p97, the Structural and Molecular Basis for Functional Disruption

Molecular Imaging of Neuroinflammation in Neurodegenerative Dementias: The Role of In Vivo PET Imaging

Neurodegeneration elicits neuroinflammatory responses to kill pathogens, clear debris and support tissue repair. Neuroinflammation is a dynamic biological response characterized by the recruitment of innate and adaptive immune system cells in the site of tissue damage. Resident microglia and infiltrating immune cells partake in the restoration of central nervous system homeostasis. Nevertheless...

Clinical, genetic and neuropathological features of frontotemporal dementia: an update and guide.

INTRODUCTION Frontotemporal Lobar Degeneration encompasses a group of heterogeneous disorders with shared behavioural and cognitive symptoms, as well as gross pathological features. The genetic underpinnings and histopathological aspects are quite diverse and form the basis of molecular classification, which is not easy to correlate with clinical findings and syndromes. Scientific research has ...

Untangling the tau gene association with neurodegenerative disorders.

Pathological tau protein inclusions have long been recognized to define the diverse range of neurodegenerative disorders called the tauopathies, which include Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration. Mutations in the tau gene, MAPT, cause familial frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), and common ...